Table 4.

Results of Univariate and Multivariate Cox Regression Analysis for Predictors of Survival in Pretreatment Glioma Patients (n = 38)

	Univatiate
	Survival		TTP
	Hazard	P	Hazard	P
Age	1.73	0.005	1.73	0.004
Gender	1.77	0.144	1.80	0.131
KPS	0.63	0.019	0.67	0.028
HV	2.30	<0.001	2.07	<0.001
ID-HV	2.69	<0.001	2.45	<0.001
TBmax	2.51	<0.001	2.34	<0.001
ID-TBmax	2.41	<0.001	2.31	<0.001
Resection*	1.21	0.604	1.16	0.664

	Multivariate
	Survival (0.390) †		TTP (0.466)
	Hazard	P	Hazard	P
Age	1.26	0.421	1.44	0.158
Gender	1.77	0.525	1.43	0.440
KPS	0.78	0.324	0.88	0.554
TBmax	2.37	<0.001	2.31	<0.001
Resection	0.76	0.516	0.75	0.463

	Survival (0.394)		TTP (0.485)
	Hazard	P	Hazard	P
Age	1.22	0.483	1.38	0.210
Gender	1.23	0.676	1.31	0.559
KPS	0.75	0.244	0.82	0.378
ID-TBmax	2.30	<0.001	2.30	<0.001
Resection	0.81	0.616	0.77	0.519

^*Resection is dichotomized as biopsy or other (gross/sub-total resection).

^†The coefficient of determination (R2) is given for each table.

Univariate analysis of hypoxia and clinical variables shows the hazard ratio with P values associated with survival and TTP at 2 years. After adjusting for clinical variables using a multivariate model, greater tumor TBmax was still associated with shorter survival and TTP. Multivariate results for HV and ID-HV appear in supplemental materials.