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. Author manuscript; available in PMC: 2016 Aug 4.
Published in final edited form as: Structure. 2015 Jul 16;23(8):1538–1549. doi: 10.1016/j.str.2015.06.007

Figure 2.

Figure 2

Illustrative examples of GPCR structural modeling with blue and red representing model and experimental structure respectively. (A) Template based modeling on human opioid (PDB ID:4ej4A1) (Granier et al., 2012) and serotonin (PDB ID: 4iarA1) (Wang et al., 2013) receptors with close homologous templates detectable by PSI-BLAST or sequence identity >30% excluded. Left to right columns are the LOMETS templates and GPCR-I-TASSER models overlaid on the native in the whole chain and TM-helix regions respectively. (B) Ab initio modeling on human Adenosine A2a receptor (PDB ID: 3emlA1) (Jaakola et al., 2008) with all homologous and membrane templates excluded. Left to right columns are the models built by MODELLER, ab initio assembly and GPCR-I-TASSER models overlaid with TM regions of the native structure, respectively.

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