Table 3.
Association of LS with cardiovascular outcomes (primary composite outcomes, CV death, incident HF hospitalization, and total number of HF hospitalizations) in univariate and multivariable analysis (n=447). Multivariable analysis is adjusted for the following variables: Model 1: age, gender, race, randomization strata (prior HF hospitalization or biomarker criteria), region of enrollment (Americas versus Russia or Georgia), randomized treatment assignment, core lab LVEF, history of atrial fibrillation, heart rate, New York Heart Association class, history of stroke, creatinine, and hematocrit; Model 2: Model 1 + LV mass, LVESVi; Model 3: Model 2 + E/E’ ratio. For dichotomous analysis, abnormal LS was defined as LS > -15.8% (see text for details). LS is shown as absolute value.
| Normal LS (≥15.8) | Abnormal LS (<15.8) | Dichotomous | Continuous (per 1% ↓) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
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| N | Events | Rate | N | Events | Rate | HR (95% CI) | P | HR (95% CI) | P | |
| Primary | ||||||||||
| Unadjusted | 216 | 37 | 5.9 (4.2–8.1) | 231 | 78 | 13.5 (10.8–16.8) | 2.26 (1.53–3.34) | <0.001 | 1.13 (1.08–1.19) | <0.001 |
| Model 1 | 203 | 36 | 6.1 (4.4–8.4) | 226 | 77 | 13.6 (10.9–17.0) | 2.15 (1.34–3.45) | 0.001 | 1.14 (1.07–1.23) | <0.001 |
| Model 2 | 155 | 28 | 6.3 (4.3–9.1) | 164 | 58 | 14.7 (11.3–19.0) | 2.14 (1.26–3.66) | 0.005 | 1.14 (1.04–1.24) | 0.003 |
| CV death | ||||||||||
| Unadjusted | 216 | 15 | 2.2 (1.3–3.7) | 231 | 39 | 5.9 (4.3–8.1) | 2.67 (1.47–4.85) | 0.001 | 1.16 (1.08–1.25) | <0.001 |
| Model 1 | 203 | 15 | 2.4 (1.4–3.9) | 226 | 38 | 5.9 (4.3–8.1) | 3.12 (1.53––6.35) | 0.002 | 1.25 (1.13–1.38) | <0.001 |
| Model 2 | 155 | 12 | 2.5 (1.4–4.4) | 164 | 31 | 6.8 (4.8–9.7) | 3.20 (1.44–7.12) | 0.004 | 1.29 (1.14–1.46) | <0.001 |
| Incident HF Hosp | ||||||||||
| Unadjusted | 216 | 25 | 4.0 (2.7–5.9) | 231 | 53 | 9.1 (7.0–11.9) | 2.24 (1.39–3.60) | 0.001 | 1.12 (1.05–1.19) | 0.001 |
| Model 1 | 203 | 24 | 4.0 (2.7–6.0) | 226 | 53 | 9.3 (7.1–12.2) | 2.11 (1.19–3.74) | 0.011 | 1.11 (1.02–1.21) | 0.021 |
| Model 2 | 155 | 18 | 4.0 (2.5–6.4) | 164 | 39 | 9.8 (7.2–13.4) | 2.23 (1.16–4.28) | 0.016 | 1.08 (0.97–1.20) | 0.15 |
| Total HF Hosp | IRR (95% CI) | P | IRR (95% CI) | P | ||||||
| Unadjusted | 216 | - | - | 231 | - | - | 2.46 (1.36–4.46) | 0.003 | 1.17 (1.06–1.28) | 0.002 |
| Model 1 | 203 | - | - | 226 | - | - | 3.36 (1.68–6.72) | 0.001 | 1.19 (1.06–1.33) | 0.002 |
| Model 2 | 155 | - | - | 164 | - | - | 4.54 (1.95–10.6) | <0.001 | 1.17 (1.03–1.33) | 0.017 |