Table 1.
Summary of anti-Ro reactivity and objective dry mouth in pSS patients in OK cohort with negative histopathology of minor salivary gland biopsy.
| 1Biopsy Negative (Focus Score <1.0) | |||
| 73/321 (22.74%)2 | |||
| Anti-Ro+ | 3Anti-Ro− | ||
| 49 (15.26%) | 24 (7.47%) | ||
| 4WUSF+ | WUSF− | WUSF+ | WUSF− |
| 33 (10.28%) | 16 (4.98%) | 14 (4.36%) | 10 (3.11%) |
1
As per AECG criteria.[8] Focus Score is defined as number of lymphocytic foci (which are adjacent to normal-appearing mucous acini and contain more than 50 lymphocytes) per 4 mm2 of glandular tissue.[21]
2
% values represent proportion of the total number of pSS patients (n=321).
3
All anti-Ro negative patients were anti-La positive and thus met AECG criteria for pSS.[8] The methods employed for autoantibody analysis in OK are provided in supplemental methods.
4
WUSF: Whole unstimulated salivary flow. A value of ≤1.5ml per 15 min is considered WUSF+.[20]