Table 1. Pearson correlation analysis of serum Aβ and metabolic markers of APP/PS1 transgenic mice after 11-week dietary manipulations.
Aβ40 | Aβ42 | BW gain | Blood glucose | leptin | hepatic TG | fat(% of BW) | serum TG | ||
---|---|---|---|---|---|---|---|---|---|
Aβ40 | R | 1 | 0.75** | 0.58** | 0.63** | 0.46* | 0.51* | 0.30 | 0.10 |
Sig | <0.001 | <0.001 | <0.001 | 0.022 | 0.011 | 0.143 | 0.681 | ||
N | 33 | 33 | 30 | 25 | 24 | 25 | 18 | ||
Aβ42 | R | 1 | 0.73** | 0.60** | 0.45* | 0.49* | 0.47* | -0.36 | |
Sig | <0.001 | <0.001 | 0.026 | 0.015 | 0.019 | 0.125 | |||
N | 33 | 30 | 25 | 24 | 25 | 18 | |||
BW gain | R | 1 | 0.56** | 0.84** | 0.82** | 0.71** | 0.13 | ||
Sig | <0.001 | <0.001 | <0.001 | <0.001 | 0.481 | ||||
N | 43 | 26 | 24 | 26 | 30 | ||||
Blood glucose | R | 1 | 0.45** | 0.72** | 0.68** | 0.40* | |||
Sig | 0.031 | <0.001 | <0.001 | 0.03 | |||||
N | 23 | 21 | 23 | 30 | |||||
leptin | R | 1 | 0.71** | 0.63** | 0.77** | ||||
Sig | <0.001 | 0.001 | 0.009 | ||||||
N | 24 | 26 | 10 | ||||||
hepatic TG | R | 1 | 0.72** | 0.67* | |||||
Sig | <0.001 | 0.036 | |||||||
N | 24 | 10 | |||||||
fat (% of BW) | R | 1 | 0.80** | ||||||
Sig | 0.005 | ||||||||
N | 10 | ||||||||
serum TG | R | 1 | |||||||
Sig | |||||||||
N |
**P< 0.01 level (2-tailed) and
* P< 0.05 level (2-tailed).
BW: body weight; fat (% of BW): epididymal fat weight (% of body weight); R: regression coefficient.