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. 2015 Aug 5;10(8):e0130496. doi: 10.1371/journal.pone.0130496

Fig 6. miR-126-3p reduces VEGF secretion and endothelial tube formation.

Fig 6

(A) miR-126-3p overexpression significantly reduced secreted VEGF levels in TPC-1 and FTC-133 cell lines but not XTC-1 cells. * p < 0.5. VEGF levels were also normalized to total protein. Culture media was harvested from TPC-1, FTC-133 and XTC-1 cells transfected with miR-NC and miR-126-3p after 72 hours of transfection. (B) Expression of VEGF protein in lung tumor metastases was decreased in mice injected with FTC-133 Luc cells transfected with miR-126-3p as compared to miR-NC. (C) Endothelial cell tube formation is decreased with miR-126-3p overexpression. All experiments were repeated at least three times.