Table 4. TeHV3 Open reading frames features.
| ORF | HV Homologue | Protein | Function/ description | Similarity* | Position | Length (nt) | Frame |
|---|---|---|---|---|---|---|---|
| 1 | HHV6 | IE2 | Transactivator | 40%77/188 | 1,097–3,916 | 2,820 | + |
| 2 | ChHV5 | ICP4 | Transactivator | 58%41/70 | 4,897–7,737 | 2,841 | - |
| 3 | N/A | UNKN | N/A | N/A | 8,948–9,580 | 633 | + |
| 4 | N/A | UNKN | N/A | N/A | 9,555–10,280 | 726 | + |
| 5 | N/A | UNKN | N/A | N/A | 10,704–11,444 | 741 | - |
| 6 | N/A | UNKN | N/A | N/A | 11,864–13,348 | 1,485 | + |
| 7 | N/A | UNKN | N/A | N/A | 13,041–14,798 | 1,398 | + |
| 8 | ChHV5 | US3a | Serine/Threonine Kinase | 54% 181/333 | 14,902–15,993 | 1,092 | + |
| 9 | ChHV5 | US3b | Putative cyclin-dependent kinase 2 | 50% 153/305 | 16,026–16,964 | 939 | + |
| 10 | ChHV5 | gD | Cell receptor ligand | 44%78/175 | 17,055–17,858 | 804 | + |
| 11 | HPV2 | gE-like | Unknown | 41%58/141 | 17,874–18,542 | 669 | + |
| 12 | N/A | UNKN | N/A | N/A | 18,557–19,957 | 1,401 | - |
| 13 | N/A | UNKN | N/A | N/A | 20,069–20,512 | 444 | + |
| 14 | ChHV5 | gE | Host interaction and immunoevasion | 41%159/387 | 20,634–22,031 | 1,398 | + |
| 15 | N/A | UNKN | N/A | N/A | 22,141–22,416 | 276 | - |
| 16 | ChHV5 | US10 | Zinc-ion binding/ Tegument/capsid protein | 54%106/194 | 22,683–23,429 | 747 | - |
| 17 | N/A | UNKN | N/A | N/A | 23,448–25,085 | 1,638 | + |
| 18 | N/A | UNKN | N/A | N/A | 25,127–25,489 | 363 | - |
| 19 | N/A | UNKN | N/A | N/A | 25,572–26,120 | 549 | - |
| 20 | N/A | UNKN | N/A | N/A | 26,268–26,969 | 702 | - |
| 21 | N/A | UNKN | N/A | N/A | 27,050–28,438 | 1,388 | - |
| 22 | ChHV5 | ICP4 | Transactivator | 58%41/70 | 29,506–32,346 | 2,841 | + |
| 23 | HHV6 | IE2 | Transactivator | 40% 77/188 | 33,327–36,146 | 2,820 | - |
| 24a | RFHVMn | Rep Protein | Unknown | 38%34/88 | 38,525–38860 | 336 | + |
| 24b | BoHV6 | Bov2.bl | Unknown | 51%44/85 | 38,574–38,906 | 333 | - |
| 25 | PsHV1 | gL | Viral entry | 58%33/56 | 39,402–39,856 | 384 | + |
| 26 | ChHV5 | UL2 | UDG glycosilase | 61%156/252 | 39,792–40,604 | 813 | + |
| 27 | ChHV5 | UL3 | Phosphoprotein | 72%154/211 | 40,685–41,266 | 582 | + |
| 28 | ChHV5 | UL4 | Nuclear protein | 50%86/172 | 41,682–42,365 | 684 | - |
| 29 | ChHV5 | UL5 | DNA helicase/primase cpx | 69%598/858 | 42,416–44,917, | 2,556 | - |
| 30 | ChHV5 | UL6 | Capsid protein | 60%398/654 | 44,955–46,964 | 2,010 | + |
| 31 | ChHV5 | UL7 | Virion egress protein | 53%132/248 | 46,807–47,622 | 816 | + |
| 32 | ChHV5 | UL8 | DNA helicase/primase cpx | 44%336/749 | 47,627–49,777 | 2,151 | - |
| 33 | AnHV1 | UL9 | Replication origin-binding protein | 57%463/810 | 49,779–52,133 | 2,355 | - |
| 34 | ChHV5 | gM | Virion assembly and egress | 66%279/418 | 52,145–53,383 | 1,239 | + |
| 35 | HSV1 | UL11 | Tegument protein | 62%27/43 | 53,433–53,672 | 240 | - |
| 36 | ChHV5 | UL12 | Alkaline exonuclease | 55%271/484 | 53,606–55,207 | 1,602 | - |
| 37 | HSV1 | UL13 | Serine/threonine kinase | 42%184/428 | 55,208–56,521 | 1,314 | - |
| 38 | ChHV5 | UL14 | Tegument protein | 58%58/100 | 56,443–56,976 | 534 | - |
| 39 | ChHV5 | UL15A | Putative DNA packing protein | 64%214/330 | 56,975–58,090 | 1,116 | + |
| 40 | ChHV5 | UL16 | Capsid binding protein | 53%179/332 | 57,938–58,945 | 1,008 | - |
| 41 | ChHV5 | UL17 | Virion Packaging protein | 46%315/676 | 58,924–60,882 | 1,959 | - |
| 42a | ChHV5 | UL15B | Terminase large subunit | 74%267/359 | 60,986–62,050 | 1,065 | + |
| 42b | ChHV5 | HP18 | Hypothetical protein | 43%34/79 | 62,069–62,523 | 453 | + |
| 42c | HHV4 | BRRF4 | BRRF4 protein | 40%41/101 | 63,118–63,579 | 462 | + |
| 43 | ChHV5 | UL18/VP23 | Capsid protein | 65%211/321 | 63,784–64,746 | 963 | - |
| 44 | ChHV5 | UL19 | Major capsid protein | 72%993/1,373 | 64,821–68,930 | 4,110 | - |
| 45 | ChHV5 | UL20 | Multifunctional essential for fusion | 75%139/184 | 69,023–69,613 | 591 | - |
| 46 | ChHV5 | UL21 | Tegument protein | 45%220/480 | 69,716–71,068 | 1,353 | + |
| 47 | ChHV6 | UL22/gH | Fusion/cell entry | 74%332/445 | 71,088–73,289 | 2,202 | - |
| 48 | ChHV5 | UL23/TK | De novo DNA synthesis | 48%168/345 | 73,322–74,389 | 1,068 | - |
| 49 | BoHV1 | UL24 | Nuclear protein | 52%94/178 | 74,371–75,345 | 975 | + |
| 50 | ChHV5 | UL25 | Virion packaging | 55%323/578 | 74,960–756,687 | 1,728 | + |
| 51 | ChHV6 | UL26 | Protease | 60%352/579 | 76,726–78,198 | 1,473 | + |
| 52 | ChHV6 | UL27/gB | Cell entry/Fusion | 73%637/864 | 78,251–80,734 | 2,484 | - |
| 53 | ChHV5 | UL28/ICP18.5 | DNA processing and packaging | 64%475/742 | 80,731–83,022 | 2,292 | - |
| 54 | ChHV5 | UL29/ICP8 | Major DNA binding protein | 63%735/1,156 | 82,976–86,527 | 3,552 | - |
| 55 | ChHV5 | UL30 | DNA polymerase | 70%809/1150 | 86,651–90,049 | 3,399 | + |
| 56 | ChHV5 | UL31 | Nuclear matrix protein | 67%185/275 | 89,991–90,878 | 888 | - |
| 57 | ChHV5 | UL32 | DNA cleavage/packaging | 63%296/466 | 90,884–92,497 | 1,614 | - |
| 58 | ChHV5 | UL33 | DNA processing and packaging | 66%72/108 | 92,478–92,825 | 348 | + |
| 59 | ChHV5 | UL34 | Inner nuclear membrane protein | 53%143/269 | 92,827–93,555 | 729 | + |
| 60 | PsHV1 | UL35 | Small capsid protein | 52%24/46 | 93,565–93,909 | 345 | + |
| 61 | ChHV5 | UL36 | Large tegument protein | 44%942/2101 | 93,906–101,630 | 7,725 | - |
| 62 | ChHV5 | UL37 | Capsid assembly | 43%461/1051 | 101,696–104,866 | 3,171 | - |
| 63 | ChHV5 | UL38 | Capsid protein | 56%256/455 | 104,868–106,211 | 1,344 | + |
| 64 | ChHV5 | UL39 | Ribonucleotide reductase L.s. | 62%490/787 | 106,315–108,705 | 2,391 | + |
| 65 | FeHV1 | UL40 | Ribonucleotide reductase S. s. | 73%220/301 | 108,728–109,642 | 915 | + |
| 66 | ChHV5 | UL41 | Virion host shutoff protein | 62%212/338 | 109,637–110,596 | 960 | - |
| 67 | ChHV5 | UL42 | DNA polymerase processivity factor | 48%147/304 | 110,732–111,838 | 1,107 | + |
| 68 | ChHV5 | UL43 | Membrane protein | 45%178/393 | 111,932–113,122 | 1,191 | + |
| 69 | EqHV3 | UL54/ICP27 | Transactivator | 50%109/214 | 113,152–114,438 | 1,287 | - |
| 70 | N/A | UNKN | N/A | N/A | 114,557–115,162 | 606 | + |
| 71 | ChHV5 | UL53/gK | Intracellular fusion | 64%227/353 | 115,194–116,234 | 1,041 | - |
| 72 | ChHV5 | UL52 | DNA primase | 55%490/880 | 116,231–118,951 | 2,721 | - |
| 73 | PsHV1 | UL51 | Tegument protein | 47%82/174 | 118,950–119,600 | 651 | + |
| 74 | MeHV1 | UL50 | Deoxyuridine triphosphatase | 50%82/163 | 119,642–120,985 | 1,344 | - |
| 75 | BoHV6 | ORF53/UL49.5 | Tegument/envelope protein | 48%48/100 | 120,984–121,286 | 303 | + |
| 76 | AnHV1 | UL49.2 | Tegument protein | 60%59/98 | 121,352–121,990 | 639 | + |
| 77 | SuHV1 | UL48 | Tegument protein | 43%163/378 | 122,083–123,369 | 1,287 | + |
| 78 | PsHV1 | UL47 | Tegument protein | 38%95/247 | 123,467–124,888 | 1,422 | + |
| 79 | AnHV1 | UL46 | Tegument protein | 42%95/223 | 124,881–126,092 | 1,212 | + |
| 80 | HHV3 | UL45 | Thymidylate synthetase | 79%98/124 | 128,556–128,930 | 375 | + |
| 81 | CeHV9 | UL44/gC | Ligand/immunoevasion | 45%104/228 | 128,974–130,026 | 1,053 | - |
| 82 | N/A | UNKN | N/A | N/A | 130,062–130,850 | 789 | - |
| 83 | N/A | UNKN | N/A | N/A | 130,954–131,490 | 537 | - |
| 84 | HHV4 | EBNA-3C | Nuclear protein | 52%39/75 | 131,690–133,450 | 1,761 | - |
| 85 | N/A | UNKN | N/A | N/A | 133,338–134,915 | 1,578 | + |
| 86 | N/A | UNKN | N/A | N/A | 134,954–136,252 | 1,299 | + |
| 87 | BoHV2 | UL55a | Unknown | 39%43/110 | 136,355–137,020 | 666 | - |
| 88 | N/A | UNKN | N/A | N/A | 137,152–137,841 | 690 | + |
| 89 | ChHV5 | UL55b | Unknown | 44%28/63 | 138,014–138,670 | 657 | - |
| 90 | N/A | UNKN | N/A | N/A | 138,799–139,494 | 696 | + |
| 91 | N/A | UNKN | N/A | N/A | 139,517–140,005 | 489 | - |
| 92 | N/A | UNKN | N/A | N/A | 140,190–142,040 | 1,851 | - |
| 93 | N/A | UNKN | N/A | N/A | 142,037–143,752 | 1,716 | - |
| 94 | N/A | UNKN | N/A | N/A | 144,464–144,760 | 297 | - |
| 95 | N/A | UNKN | N/A | N/A | 144,780–145,166 | 387 | + |
| 96 | N/A | UNKN | N/A | N/A | 145,269–146,831 | 1,563 | - |
| 97 | N/A | UNKN | N/A | N/A | 146,976,-148,493 | 1,518 | - |
| 98 | N/A | UNKN | N/A | N/A | 148,510–148,968 | 459 | + |
| 99 | N/A | UNKN | N/A | N/A | 149,077149,700 | 624 | - |
*The number at the denominator indicates the total length of the portion of the herpesviral homologous protein being compared by BLAST with TeHV3. The number at the numerator indicates the actual number of the amino acid residues of TeHV3 showing similarities with the compared portion of the homologous protein. The percentage summarizes the overall similarity between TeHV3 and the specific herpesvirus homologous protein for the specific motif considered.