Fig. 5.

Mean areas-under-the-curve for radiochromatograms for [¹⁸F]flutemetamol parent and ¹⁸F-labelled metabolities in plasma as function of time following administration of flutemetamol (¹⁸F) injection. Error bars are ±1 standard deviation. The fraction of the parent compound ([¹⁸F]flutemetamol) in the plasma decreased from 75 % at 5 min to 8.3 % at 25 min with the majority of the plasma activity bound to hydrophilic metabolites