Fig. 1.
Partial regression plots showing opposing relationships between response to pain > no-pain in bilateral anterior insula (AI), inferior frontal gyrus (IFG), and midcingulate cortex (midCC), as well as unique variances associated with affective-interpersonal and lifestyle-antisocial psychopathic traits after the other dimension had been controlled for (a similar pattern was also seen in the anterior cingulate cortex [ACC], adjacent to midCC). (Left) Negative relationships between blood oxygenation-level-dependent (BOLD) response to pain > no-pain and affective-interpersonal traits after controlling for the effect of lifestyle-antisocial traits. (Right) Positive relationships between BOLD response to pain > no-pain and lifestyle-antisocial traits after controlling for the effect of affective-interpersonal traits. R 2 reflects the partial correlation coefficients of determination. The insets show horizontal and midsagittal sections of the bilateral AI (z = 0), IFG (z = 15), and midCC (x = 0) regions of interest, overlaid on an average T1 structural image from all participants