Fig. 3.

Effects of TAK-733 on the growth of human lung carcinoma A549 tumors in a xenograft rat model. Oral once-daily administration of TAK-733 (1, 3, 10 mg/kg) or vehicle was initiated when tumors reached a weight of 224–297 mg in A549 tumor-bearing rats. Data are expressed as mean + standard deviation (SD) (n = 8/group). Black, blue, green and red lines and markers indicate the vehicle, and TAK-733 1, 3, and 10 mg/kg dosage groups, respectively. Left A549 tumor weight (mg), right percentage change in tumor weight from day 0. *1: P < 0.05 vs. vehicle (Wilcoxon rank-sum test)