Fig. 6.

SUVmean values following TAK-733 (1, 3, 10 mg/kg) or vehicle treatment in human lung carcinoma A549 tumors in a xenograft rat model. ¹⁸F-FDG-PET scans were performed on days 0, 2, 4, 7, 10, and 14. Data are expressed as mean + standard deviation (SD) (n = 8/group). Black, blue, green and red lines and markers indicate vehicle, 1, 3, and 10 mg/kg group, respectively. ¹⁸ F-FDG-PET ¹⁸F-Fluorodeoxyglucose-positron emission tomography, SUVmean mean standard uptake. Left absolute SUVmean, right percentage change in SUVmean from day 0. *1: P < 0.05 vs. vehicle (Wilcoxon rank-sum test), *2: P < 0.05 vs. TAK-733 1 mg/kg (Wilcoxon rank-sum test), *a: P < 0.05 vs. pretreatment (Wilcoxon rank-sum test)