Table 1.

Mean %T/C values for median tumor weight by dosage group and day of study in A549 tumor-bearing rats receiving once-daily oral administration of TAK-733 (1, 3, 10 mg/kg) or vehicle for 2 weeks (n = 8/group)

TAK-733 dosage group	%T/C values by day of study
	0	1	3	7	9	11	14
Vehicle	100	100	100	100	100	100	100
1 mg/kg	76	82	71	78	68	60	55
3 mg/kg	93	102	70	68	53	42	44
10 mg/kg	84	83	62	47	37*	36*	31*

%T/C ratio of median tumor weight in the treated versus control (vehicle) group × 100

*%T/C value ≤41 % (National Cancer Institute threshold for significant anti-cancer activity)