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. 2015 Aug 5;10(8):e0133892. doi: 10.1371/journal.pone.0133892

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© 2015 Delebinski et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — A. HL-60 cells were treated with depicted VAE concentrations (~IC50) for 18 h. Cell lysates were incubated with a human apoptosis array detecting the relative expression of apoptosis-related proteins per sample. Each experiment was carried out in duplicate (n = 2). VAE treatment changes the expression of apoptosis associated proteins resulting in an increase of TRAIL-R1 and a decrease in several proteins including XIAP, survivin, claspin and p53. B. The down-regulation of survivin, XIAP, p53 and claspin was confirmed by Western blot. C. Activity of TRAIL-receptor-1 and -2 was measured by FITC-labelled monoclonal antibody and flow cytometry after treatment of HL-60 cells with distinct VAE concentrations for 18 h.