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. 2015 Aug 5;10(8):e0133892. doi: 10.1371/journal.pone.0133892

Fig 6. In vivo efficacy of Viscum album L. extracts.

Fig 6

NOD/SCID/IL2rg mice carrying systemic human promyelotic leukaemia cells (HL-60) were treated with a dose-escalation regimen of 20/40/60/ mg/kg oleanolic acid (TT), 0.3/0.4/0.5 μg/kg lectin (viscum) or a combination thereof (viscumTT), three times per week for two weeks post-transplantation of cells. Each concentration were given twice (i.v.), starting on day three after tumor cell injection. One group was treated with cytarabine and one with cytarabine plus viscumTT. Control mice received equal amounts of cyclodextrins. The treatment with viscumTT had a significant therapeutic advantage compared to the single extracts TT and viscum.