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. 2015 Aug 5;10(8):e0134911. doi: 10.1371/journal.pone.0134911

Table 5. KEGG pathway enrichment analysis of the upregulated and downregulated genes in DM and LM after UVB irradiation.

  DM   LM  
  Pathway Adj-p Pathway Adj-p
Upregulated at 6h p53 signaling pathway 9.49E-07 p53 signaling pathway 7.04E-07
Ribosome 3.00E-04 Ribosome 2.43E-06
Upregulated at 12h Ribosome 3.22E-11 Systemic lupus erythematosus 1.16E-06
RNA transport 7.11E-07 Ribosome 1.47E-06
Ribosome biogenesis in eukaryotes 7.00E-04 p53 signaling pathway 1.10E-03
p53 signaling pathway 2.13E-02 Mismatch repair 5.40E-03
    Pathways in cancer 6.90E-03
    Apoptosis 7.90E-03
Upregulated at 24h Ribosome 1.06E-09 Ribosome 7.38E-06
p53 signaling pathway 1.50E-03    
Downregulated at 6h Adherens junction 1.51E-08 Ubiquitin mediated proteolysis 6.84E-12
Ubiquitin mediated proteolysis 7.21E-08 Adherens junction 5.23E-11
Wnt signaling pathway 9.12E-06 Endocytosis 6.14E-06
Colorectal cancer 3.53E-05 Wnt signaling pathway 3.14E-05
Progesterone-mediated oocyte maturation 4.04E-05 Progesterone-mediated oocyte maturation 5.32E-05
Endocytosis 6.24E-05 Cell cycle 7.36E-05
Pathways in cancer 7.60E-05 Insulin signaling pathway 5.00E-04
Systemic lupus erythematosus 1.00E-04 Oocyte meiosis 7.00E-04
Cell cycle 9.00E-04 Pathways in cancer 7.00E-04
Oocyte meiosis 1.00E-03 Colorectal cancer 1.20E-03
Endometrial cancer 1.10E-03 Neurotrophin signaling pathway 2.60E-03
Fc epsilon RI signaling pathway 1.70E-03 Fc gamma R-mediated phagocytosis 8.60E-03
B cell receptor signaling pathway 1.80E-03 Endometrial cancer 1.18E-02
ErbB signaling pathway 1.90E-03 Chronic myeloid leukemia 1.54E-02
Fc gamma R-mediated phagocytosis 2.20E-03 Bacterial invasion of epithelial cells 1.76E-02
T cell receptor signaling pathway 2.50E-03 Fc epsilon RI signaling pathway 2.11E-02
Insulin signaling pathway 5.30E-03 Chemokine signaling pathway 4.22E-02
Neurotrophin signaling pathway 1.97E-02 ErbB signaling pathway 4.22E-02
    T cell receptor signaling pathway 4.22E-02
Downregulated at 12h Metabolic pathways 4.43E-05 Protein processing in endoplasmic reticulum 2.00E-03
Adherens junction 1.00E-04    
Fc gamma R-mediated phagocytosis 3.00E-04    
Propanoate metabolism 1.10E-03    
Protein processing in endoplasmic reticulum 2.70E-03    
Systemic lupus erythematosus 3.10E-03    
Purine metabolism 4.90E-03    
Regulation of actin cytoskeleton 1.20E-02    
Valine, leucine and isoleucine degradation 4.30E-02    
Pyrimidine metabolism 4.30E-02    
Downregulated at 24h     Cell cycle 2.20E-08
    Systemic lupus erythematosus 8.56E-06
 -   DNA replication 2.54E-05
    Oocyte meiosis 2.00E-03
    Lysine degradation 2.12E-02