Table 1. Study characteristics and overall effect for main outcome and total mortality for studies not registered in ClinicalTrials.gov prior to publication.

Study	Acronym	Start Year	Pub Year	Primary Outcome (PO)	Primary Outcome	Total Mortality
Asymptomatic Carotid Artery Progression Study	ACAPS	1988	1994	3-year change in IMT wall of CA	Benefit	Benefit
Aspiring Myocardial Infarction Study	AMIS	1974	1980	All-cause mortality	Null	Null
Boston Area Anticoagulation Trial for Atrial Fibrillation	BAATAF	1985	1990	Prevalence of stroke	Benefit	Benefit
Beta-Blocker Heart Attack Trial	BHAT	1977	1982	All-cause mortality	Benefit	Benefit
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation	Carotid	1986	1992	>50% restenosis at 1 year	Null	NP
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation	CASCADE	1987	1993	Composite of survival free of various cardiac events	Benefit	Null
Cardiac Arrhythmia Suppression Trial	CAST	1986	1991	Cardiac death or arrest	Harm	Harm
Coronary Drug Project	CDP	1965	1975	All-cause mortality	Null	Null
Coronary Intervention Study	CIS	1971	1984	Progression of CAD	Null	Null
Cholesterol-lowering atherosclerosis study	CLAS	1979	1987	Atherosclerosis regression	Benefit	NR
Coronary Primary Prevention Trial	CPPT	1971	1984	CHD death or definite non-fatal MI	Null	Null
Familial Atherosclerosis Treatment Study	FATS	1984	1990	Regression primary artery	Benefit	NP
(Fenfluramine & Phentemrine) Cardiovascular System in Obesity: Effect of Treatment	FEN-PHEN	1983	1992	Weight loss	Benefit	NR
Fish oil on blood pressure among mild hypertensive subjects	FISH OIL	1983	1993	Blood pressure	Null	NR
Hypertension Control Program	HCP	1980	1987	Normative bp	Benefit	NP
Hypertension Detection and Follow-up Program	HDFP	1971	1979	All-cause mortality	Benefit	Benefit
Hypertension Prevention Trial	HPT	1981	1990	Composite of on medication or dbp>90 sbp>140	Benefit	NP
Potassium chloride on blood pressure in hypertensive men	KCL	1983	1990	Reinstated blood pressure med	Null	NR
Multicenter Investigation of Limitation of Infarct Size	MILIS	1977	1984	Infarct size	Null	Null
Myocardial Infarction Triage and Intervention Trial	MITIT	1988	1993	Ranked composite of death, stroke, bleeding, infarct size	Null	Null
Multiple Risk Factor Intervention Trial	MRFIT	1974	1982	CHD death	Null	Null
Immunosuppressive therapy for myocarditis	MYOCARDITIS	1986	1995	Change in left ventricular infarction size	Null	Null
Postmenopausal Estrogen/Progestin Interventions Study	PEPI	1994	1995	Lipoproteins, blood pressure	Benefit	NR
Physician’s Health Study	Physicians Health Study	1981	1989	MI infarction	Benefit	Null
Stanford Coronary Risk Intervention Project	SCRIP	1983	1994	Angiographic change of diameter	Benefit	Null
Systolic Hypertension in the Elderly Program	SHEP	1984	1996	Major CVD events	Benefit	Null
Studies of Left Ventricular Dysfunction	SOLVD	1975	1991	All-cause mortality	Benefit	Benefit
Late thrombolytic therapy preserves left ventricular function	Thrombo	1982	1989	Change in angiographic endpoint ejection fraction	Benefit	Null
Thrombolysis in myocardial infarction	TIMI	1983	1985	Reperfusion	Benefit	NP
Treatment of Mild Hypertension Study	TOMHS	1985	1993	Major CVD events	Null	NR