Fig. 2.
Dialysis of 0.5 mM of the antagonist MDL 11939 (MDL) (n = 6) in the ventral respiratory column (VRC) had no significant effect (P ≥ 0.160) on frequency (F, breaths/min, B) or tidal volume (VT, liters/breath, C) relative to time-control studies (n = 7). However, MDL had a modestly significant effect on minute ventilation (VI, liters/min, P = 0.046, A). The first data point represents the last 15-min bin of hour 1. Closed symbols and bar indicate period of MDL dialysis; open symbols indicate mock cerebral spinal fluid (mCSF) dialysis. F and P indicate values for interaction term from two-way repeated-measures (RM) ANOVA. #P ≤ 0.05 between groups per post hoc analysis.