Fig. 4.
Dialysis of a double cocktail of antagonists [5 mM atropine (ATR), 267 μM Spantide I (SPA, an NK1 receptor antagonist), n = 5] in the VRC had no significant effect (P ≥ 0.084) on any respiratory parameter relative to time-control studies (n = 7). A: minute ventilation (VI, liters/min); B: frequency (F, breaths/min); C: tidal volume (VT, liters/breath). The first data point represents the last 15-min bin of hour 1. Closed symbols and bar indicate period of cocktail dialysis; open symbols indicate mCSF dialysis. F and P indicate values for interaction term from two-way repeated-measures ANOVA.