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. 2015 Jul 31;5(7):e330. doi: 10.1038/bcj.2015.58

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PD-1^hiTIM3⁺ cells produce less cytokines in response to anti-CD3/anti-CD28 stimulation. Production of TNF-α, IFN-γ and IL-2 upon in vitro anti-CD3/anti-CD28 stimulation. Shown is cytokine release from CD4⁺ (a) or CD8⁺ (b) T cells gated on each fraction of cells based on PD-1 and TIM-3 expression. Representative plots from a single relapse patient (09) are shown.