Table 4. Multivariate analysis (Cox regression) on the disease-free survival and overall survival.

Variables	Overall survival				Disease-free survival
		95% CI				95% CI
	RR	Lower	Upper	P	RR	Lower	Upper	P
Agea	2.426	1.736	3.391	<0.001b	1.431	1.084	1.888	0.011b
WBCc	2.127	1.481	3.056	<0.001b	1.762	1.309	2.370	<0.001b
Karyotyped	1.971	1.035	3.751	0.039b	1.935	1.181	3.168	0.009b
NPM1/FLT3-ITDe	0.304	0.147	0.631	0.001b	0.304	0.162	0.567	<0.001b
CEBPAf	0.423	0.211	0.848	0.015b	0.596	0.367	0.970	0.037b
IDH2g	0.563	0.292	1.086	0.087	0.937	0.595	1.475	0.778
WT1	2.387	1.387	4.109	0.002b	2.315	1.505	3.561	<0.001b
RUNX1	2.103	1.210	3.656	0.008b	1.985	1.271	3.100	0.003b
ASXL1	0.726	0.403	1.306	0.285	0.941	0.544	1.628	0.828
DNMT3A	2.204	1.336	3.637	0.002b	2.134	1.398	3.256	<0.001b
TP53	4.684	2.073	10.584	<0.001b	2.547	1.244	5.214	0.011b

Abbreviations: CI, confidence interval; RR, relative risk.

^aAge >50 years relative to age ≤50 years (the reference).

^bStatistically significant (P<0.05).

^cWhite blood cell (WBC) count >50 000/μl vs ≤50 000/μl.

^dUnfavorable cytogenetics vs others.

^eNPM1^mut/FLT3-ITD^neg vs other subtypes.

^fCEBPA^{double-mutation} vs others.

^gIDH2 mutations included R140 and R172 mutations.