Figure 3.
The Vglut2f/f;Emx1-Cre mice do not show any altered response to amphetamine. The initial response to novel environment (30 min) and overall response after i.p. injection of saline (90 min), 10 mg/kg, in locomotion, periferal activity, and corner activity are unaltered in the Vglut2f/f;Emx1-Cre cKO mice compared to control mice (B, D, F). On day 2, the mice were subjected to the activity boxes for 30 min and were thereafter administered 1.5 mg/kg amphetamine i.p. and were recorded for 90 min (A, C, E). The arrows in the graphs depict the time of saline and amphetamine injection. Data were analysed with two-way ANOVA and showed no significant interactions (effect of genotype). Data are represented as mean ± SEM. cKO = conditional knock-out.