Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Stool consistency
Systematic review	Adults (aged 18 years or older) with chronic constipation 6 RCTs in this analysis	Mean difference for proportion of bowel movements of normal consistency (normal consistency not further defined) with prucalopride with control Absolute results not reported	Mean difference 9.16% 95% CI 7.28% to 11.03% Significant heterogeneity between studies (I2 = 88%, P for heterogeneity <0.00001; see Further information on studies) The analysis included 5 placebo-controlled RCTs and 1 RCT (240 people) that used PEG3350 as a control	Effect size not calculated	prucalopride