Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	Adults (at least 90% over the age of 16 years) diagnosed with idiopathic chronic constipation (mostly with modified Rome II criteria) 6 RCTs in this analysis	Total number of adverse events with prucalopride with placebo Absolute results not reported	RR 1.14 95% CI 1.05 to 1.24	Small effect size	placebo
Systematic review	Adults (at least 90% over the age of 16 years) diagnosed with idiopathic chronic constipation (mostly with modified Rome II criteria) 6 RCTs in this analysis	Serious adverse events with prucalopride with placebo Absolute results not reported	RR 0.88 95% CI 0.58 to 1.34 There was 1 episode of supraventricular tachycardia in the prucalopride group; no other cardiovascular events were reported		Not significant
Systematic review	Adults (>90% aged >16 years) diagnosed with idiopathic chronic constipation (mostly with modified Rome II criteria) 6 RCTs in this analysis	Diarrhoea with prucalopride with placebo Absolute results not reported	RR 2.72 95% CI 1.80 to 4.13	Moderate effect size	placebo
Systematic review	Adults (>90% aged >16 years) diagnosed with idiopathic chronic constipation (mostly with modified Rome II criteria) 6 RCTs in this analysis	Nausea with prucalopride with placebo Absolute results not reported	RR 1.98 95% CI 1.39 to 2.82	Small effect size	placebo
Systematic review	Adults (>90% aged >16 years) diagnosed with idiopathic chronic constipation (mostly with modified Rome II criteria) 6 RCTs in this analysis	Headache with prucalopride with placebo Absolute results not reported	RR 1.70 95% CI 1.25 to 2.31	Small effect size	placebo