Table 1.

Full search strategy for each database.

Database	Query	Query text
PubMed
	Query #1 (keywords)	(pharmacovigilance[MeSHa Terms] OR pharmacovigilance[All Fields] OR ADRb[All Fields] OR ADEc[All Fields] OR (("adverse reaction"[All Fields] OR "adverse event"[All Fields] OR "side effect"[All Fields]) AND (drug[All Fields] OR medication[All Fields] OR pharmaceutical product*[All Fields]))) AND ("social media"*[All Fields] OR “Web 2.0”[TIABd] OR “Web 2.0”[TIAB] OR "social media" [TIAB] OR "social network*" OR Twitter OR Facebook OR blog OR forum* OR fora OR message board* OR comment* OR (user feedback*))
	Query #2 (MeSH terms)	(((("pharmacovigilance"[MeSH]) OR surveillance[Title])) AND (((((Twitter[Title/Abstract]) OR Facebook[Title/Abstract]) OR Doctissimo[Title/Abstract])) OR (((((((((social media[Title/Abstract]) OR social networks[Title/Abstract]) OR "online health community"[Title/Abstract]) OR "online discussion"[Title/Abstract]) OR medical data mining[Title/Abstract]) OR online[Title/Abstract]) OR patient forum[Title/Abstract]) OR natural language processing[MeSH Terms]) OR "natural language processing"[Title/Abstract]))) OR ((((("Adverse Drug Reaction Reporting Systems"[MeSH]) AND (((((Twitter[Title/Abstract]) OR Facebook[Title/Abstract]) OR Doctissimo[Title/Abstract])) OR (((((((((social media[Title/Abstract]) OR social networks[Title/Abstract]) OR "online health community"[Title/Abstract]) OR "online discussion"[Title/Abstract]) OR medical data mining[Title/Abstract]) OR online[Title/Abstract]) OR patient forum[Title/Abstract]) OR natural language processing[MeSH Terms]) OR "natural language processing"[Title/Abstract])))) OR (((((((((((social media[Title/Abstract]) OR social networks[Title/Abstract]) OR "online health community"[Title/Abstract]) OR "online discussion"[Title/Abstract]) OR medical data mining[Title/Abstract]) OR online[Title/Abstract]) OR patient forum[Title/Abstract]) OR natural language processing[MeSH Terms]) OR "natural language processing"[Title/Abstract])) AND Adverse Drug Reaction Reporting Systems[MeSH Terms])) OR (("Adverse Drug Reaction Reporting Systems"[MeSH]) AND "Internet"[Mesh]))
Embase	Query #3	"pharmacovigilance"/de OR ADR OR ADE OR ("adverse reaction"/de OR "adverse event" OR "side effect"/de AND ("drug"/de OR "medication"/de OR "pharmaceutical product")) AND ("social media"/de OR "Web 2.0":ab,tie OR "Web 2.0":ab,ti OR "social media":ab,ti OR "social network"/de OR Twitter OR Facebook OR blog OR forum OR fora OR "message board" OR comment OR "user feedback")

^aMeSH: Medical Subject Heading

^bADR: adverse drug reaction

^cADE: adverse drug event

^dTIAB: title and abstract

^eab, ti: abstract, title