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. 2015 Aug 7;14:99. doi: 10.1186/s12933-015-0262-8

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© Zhao et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — HDAC inhibition reduced apoptosis in STZ-induced diabetic heart. a Representative Western blots of active caspase-3. b densitometric analysis of active caspase-3 proteins. c Quantitative analysis of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL)-positive nuclei in myocardium in different groups. d Representative images of TUNEL stainings in myocardial sections. Nuclei were stained in blue (DAPI) and cardiomyocytes in red (α-sarcomeric actinin); TUN EL-positive nuclei were stained in green. α-Sarc Act α-sarcomeric actinin; Values are shown as mean ± SEM (n = 3 per group for Western blots, n = 5 per group for TUNEL); *p < 0.05 vs CTRL, ^# p < 0.05 vs STZ+ NaBu. NaBu sodium butyrate. Scale bar 100 µm.