. Author manuscript; available in PMC: 2015 Aug 6.

Published in final edited form as: Handb Exp Pharmacol. 2014;223:1143–1176. doi: 10.1007/978-3-319-05161-1_18

Table 1.

Mammalian TRPM channels

Name	Regulation/function	Phosphoinositide effects
TRPM1	Mutation causes night blindness in humans	No phosphoinositide effect reported yet
TRPM2	Activated by ADP ribose	Poly-lysine inhibits, and PI(4,5)P₂ re-activates in excised patches (Toth and Csanady, 2012)
TRPM3	Heat, pregnenolon sulphate	No phosphoinositide effect reported yet
TRPM4	Intracellular Ca²⁺ activates, non-selective Ca²⁺ impermeable cation channel	PI(4,5)P₂ activates in excised patches (Zhang et al., 2005; Nilius et al., 2006)
TRPM5	Intracellular Ca²⁺ activates non-selective Ca²⁺ impermeable cation channel	PI(4,5)P₂ activates in excised patches (Liu and Liman, 2003)
TRPM6	Mg²⁺ transporter, mutation causes human disease	PI(4,5)P₂ activates in excised patches, rapamycin-inducible 5 phosphatase and ciVSP inhibits (Xie et al., 2011)
TRPM7	cAMP, shear stress, plays important roles in development	PI(4,5)P₂ activates in excised patches, activation of PLC inhibits (Runnels et al., 2002). PI(4,5)P₂ is needed for the activity of the cardiac magnesium- inhibited TRPM7-like channels (Gwanyanya et al., 2006). Role of PLC mediated inhibition is challenged (Takezawa et al., 2004; Langeslag et al., 2007)
TRPM8	Cold, Menthol	PI(4,5)P₂ activates in excised patches (Liu and Qin, 2005; Rohacs et al., 2005; Yudin et al., 2011) PI(4,5)P₂ depletion inhibits (rapamycin, ciVSP), plays a role in desensitization (Rohacs et al., 2005; Daniels et al., 2009; Yudin et al., 2011) PI(4,5)P₂ but not PI(4)P activates in planar lipid bilayers (Zakharian et al., 2009; Zakharian et al., 2010) PI(4,5)P₂ regulates temperature threshold (Fujita et al., 2013)