Table 3.
Mammalian TRPC channels and drosophila orthologues,
| Name | Regulation/function | Phosphoinositide effects |
|---|---|---|
| dTRPL | Activated downstream of PLC, drosophila vision |
PI(4,5)P2 inhibits in excised patches (Estacion et al., 2001) PI(4,5)P2 activates but PI(4)P and PI inhibits in excised patches (Huang et al., 2010) |
| TRPC1 | Activated downstream of PLC | PI(4,5)P2 activates in excised patches, native cells (Saleh et al., 2009b, a; Shi et al., 2012) |
| TRPC3 | Activated downstream of PLC, DAG activates |
PI(4,5)P2 activates in excised patches, expression system (Lemonnier et al., 2008) VSP inhibits (Imai et al., 2012; Itsuki et al., 2012) |
| TRPC4 | Activated downstream of PLC | TRPC4α but not TRPC4β is inhibited by PI(4,5)P2, whole cell patch clamp (Otsuguro et al., 2008) TRPC4β is inhibited by PI(4,5)P2 depletion (rapamycin- inducible phosphatase) (Kim et al., 2013) |
| TRPC5 | Activated downstream of PLC, | PI(4,5)P2 activates in excised patches, but inhibits in whole cell, PI(4,5)P2 depletion may inhibit or activate it (Trebak et al., 2009) PI(4,5)P2 inhibits desensitization in whole-cell patch clamp (Kim et al., 2008b) PI(4,5)P2 activates in excised patch in complex with TRPC1 in native cells, but inhibits in the absence of TRPC1 (Shi et al., 2012) |
| TRPC6 | Activated downstream of PLC, DAG activates |
PI(4,5)P2 activates in excised patches (expression system) (Lemonnier et al., 2008) VSP inhibits (Imai et al., 2012; Itsuki et al., 2012) PI(4,5)P2 inhibits in excised patches (native smooth muscle cells) (Albert et al., 2008; Ju et al., 2010) Extracellular PI(4,5)P2 enhances its activity in platelets (Jardin et al., 2008) Calmodulin inhibits by displacing PI(3,4,5)P3 (Kwon et al., 2007) |
| TRPC7 | Activated downstream of PLC, DAG activates |
PI(4,5)P2 activates in excised patches, expression system (Lemonnier et al., 2008) VSP inhibits (Imai et al., 2012; Itsuki et al., 2012) PI(4,5)P2 inhibits in excised patches, native channels (Ju et al., 2010) |