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. Author manuscript; available in PMC: 2015 Aug 6.
Published in final edited form as: Handb Exp Pharmacol. 2014;223:1143–1176. doi: 10.1007/978-3-319-05161-1_18

Table 4.

Other TRP channels

Name Regulation/function Phosphoinositide effects
TRPA1 Mustard oil and other noxious
chemicals		 PI(4,5)P2 inhibits heterologous desensitization by capsaicin
(Akopian et al., 2007)
PI(4,5)P2 activates in excised patches, inhibits desensitization
in whole cell (Karashima et al., 2008)
PI(4,5)P2 inhibits sensitization by PAR in whole-cell
(Dai et al., 2007)
PI(4,5)P2 inhibits in excised patches in the presence of PPPi,
no effect w/o PPPi (Kim and Cavanaugh, 2007;
Kim et al., 2008c)
Depletion of PI(4,5)P2 with rapamycin-inducible phosphatase
have no effect (Wang et al., 2008)
TRPML1 Intracellular channel, mutation
causes mucolipidosis		 Specifically activated by PI(3,5)P2 (Dong et al., 2010;
Zhang et al., 2012a)
TRPP2 Mutated in polycystic kidney
disease, Mechanosensor?		 PI(4,5)P2 inhibits, depletion of PI(4,5)P2 by EGF activates
(Ma et al., 2005)