Table 2.
Characteristics of patients with decompensated DIC at presentation
| No. | AML subtype | Age (years) | Sex | PB (103/µL) | Platelets (103/µL) | Fg (g/L) | D-dimer (mg/L) | TF PCA (AU/106 cells) | MP TF PCA | TF antigen (pg/mL) | DNA (ng/mL) | LDH (U/L) | Clinical outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M1 | 74 | ♀ | 287 | 25 | 0.8 | 36.2 | 1,483 | No | n. d. | n. d. | 924 | Deceased after 3 days (fatal PE) |
| 2 | M3 (APL) | 61 | ♀ | 97 | 14 | 0.8 | 26.4 | 6,141 | Yes | n. d. | n. d. | n.d. | Deceased after 2 days (fatal ICH) |
| 3 | M5 | 69 | ♂ | 1 | 114 | 0.3 | 32.9 | 9,939 | n. d. | 32 | 220 | 1,663 | Deceased after 4.3 months |
| 4 | M3 (APL) | 56 | ♂ | 6 | 36 | 0.6 | 35.1 | 4,045 | Yes | 101 | 77 | 1,881 | Alive at 69 months follow-up |
| 5 | M5 | 73 | ♂ | 1 | 43 | 0.6 | 34.1 | 11,070 | No | 40 | 38,716 | 6,841 | Deceased after 6 days (fatal ACS) |
| 6 | M1 | 74 | ♀ | 40 | 88 | 0.6 | 22.1 | 4,515 | Yes | 115 | 1,513 | 1,409 | Alive at 23 months follow-up |
| 7 | M2 | 69 | ♀ | 79 | 80 | 0.9 | 35.4 | 515 | Yes | 72 | 222 | 566 | Alive at 52 months follow-up |
| 8 | M3 (APL) | 47 | ♂ | 1 | 21 | 1.0 | 35.4 | 22,779 | Yes | 43 | 344 | 429 | Deceased after 2.9 months (fatal pneumonia) |
| 9 | M3 (APL) | 39 | ♀ | 89 | 25 | 0.8 | 21.3 | 1,693 | n. d. | n. d. | n. d. | 3,072 | Deceased after 5 days (fatal ICH) |
| 10 | M2 | 70 | ♂ | 39 | 51 | 0.6 | 34.0 | 2,537 | Yes | 76 | 3,086 | 1,444 | Deceased after 8.3 months |
| 11 | M4 | 21 | ♂ | 115 | 61 | 1.0 | 34.0 | 5,926 | No | 141 | 450 | 2,140 | Deceased after 4.4 months (recurrent AML with DIC) |
Tissue factor procoagulant activity (TF PCA), expressed as arbitrary units (AU), is of intact peripheral blood mononuclear cells. Reference ranges are as follows: platelets, 150–400 × 103/µL; fibrinogen, 1.8–4.0 g/L; D-dimer, 0–0.5 mg/L; LDH, 84–246 U/L.
ACS acute coronary syndrome, APL acute promyelocytic leukemia, Fg fibrinogen, ICH intracerebral hemorrhage, LDH lactate dehydrogenase, MP microparticle, PE pulmonary embolism, PB peripheral blasts.