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. 2015 Aug 1;8(8):969–976. doi: 10.1242/dmm.018176

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Ocular photodetection. (A) Exposure to a light stimulus triggered a significant decrease in pupil diameter in WT mice but not in Bst^+/− mice, indicating that PLR in Bst^+/− mice is impaired. (B) Mice actograms were used to record circadian rhythm wheel-running activity for WT and Bst^+/− mice. Similar wheel-running activity patterns were observed in WT and Bst^+/− mice, showing normal circadian rhythms preserved in Bst^+/− mice. The light cycles are represented by shaded areas for dark periods and unshaded areas for light periods. Activity bouts are represented as histogram bars.