Fig. 2.

The coordinated movement of mice deficient for Sun1 and/or Sun2. (A) Motor coordination of 3- to 4-month-old WT and Sun1^−/− mice was tested using rotarod. The number of mice tested for each gender are indicated. The time to fall off the rotarod (latency) was recorded. (B) Similar to A, the time to fall off the rotarod from age-matched (3-4 months old) animals with genotypes WT, Sun1^−/−, Sun1^+/−Sun2^−/−, and Sun1^−/−Sun2^+/−. Mean±s.e.m. for each genotype is presented. (C,D) Footprint analysis obtained from 5- to 6-month-old WT, Sun1^−/−, Sun1^+/−Sun2^−/−, and Sun1^−/−Sun2^+/− animals. (D) Footprint analysis statistics and the mean±s.e.m. for each genotype is presented. Each data point represents the averaged stride length from 5 or 6 steps of each mouse. Student's t-test.