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Gpa33−/− mice are not prone to sporadic CRC. Mice were injected with AOM (10 mg/kg body weight) six times at weekly intervals to induce sporadic CRC. (A) Tumour number and (B) tumour area per mouse colon at collection was similar in Gpa33−/− and WT mice. (C) Size distribution of sporadic CRC tumours across all Gpa33−/− and WT mice at the end of the experiment. Mean±s.e.m.; n=6-9.
