Adenosine |
Drug encapsulated into silk microspheres, loaded into silk sponges and coated with drug-loaded silk films |
Duration of sustained in vitro adenosine release corresponded to duration of in vivo therapeutic effect (seizure suppression in a kindled rat model of epilepsy)
Bioactivity of adenosine encapsulated in silk preserved in vivo up to 10 days
|
Wilz et al., 2008; Szybala et al., 2009
|
Chlorophyll a β-carotene Astaxanthin |
Adsorption onto silk powder |
|
Ishii et al., 1995 |
Antioxidants from crude olive leaf extract (oleuropein and rutin) |
Adsorption onto silk powder |
|
Bayçin et al., 2010 |
Doxycycline Ciprofloxacin |
Adsorption onto silk fibers |
|
Choi et al., 2004 |
Curcumin |
Encapsulated in silk nanoparticles |
|
Gupta et al., 2009 |
Various antibiotics (penicillin, tetracycline, rifampicin, erythromycin) |
Various immobilization approaches, including bulk loading, adsorption and encapsulation |
Storage of penicillin and tetracycline in bulk-loaded silk films improved stability compared to storage in solution or as dry powder
Stabilization persisted above physiological temperatures (e.g. up to 60°C) at least 6 months
Bioactivity of erythromycin sustained over a month in hydrated sponge
|
Pritchard et al., in preparation |
Tetracycline |
Bulk loaded silk films (silk and antibiotic solutions mixed, cast on microneedle array PDMS molds, dried; films rendered insoluble by water annealing or methanol) |
|
Tsioris et al., 2011 |
Doxorubicin |
Bulk loaded silk films (silk and antibiotic solutions mixed, cast on microprism array (MPA) PDMS molds, dried; films rendered insoluble by water annealing) |
After 3 weeks stored at -20°C (frozen) and 60°C, fluorescence of the doxorubicin stored in silk films did not significantly decrease, compared to less than 80% and 30% of fluorescent doxorubicin remaining when stored in solution at -20°C and 60°C, respectively
|
Tao et al., submitted |
Phenol-sulfon-phthlein (Phenol Red) |
Bulk loaded silk films (silk and HRP solutions mixed, cast on nanopatterned PDMS molds, dried; films rendered insoluble by water annealing) |
|
Lawrence et al., 2008 |
4-amino-benzoic acid |
Chemically coupled to silk film |
|
Tsioris et al., 2010 |