Table 2.

Details of the eight SNPs in seven genes that showed significant cross-validated association with antibody response.

gene	chromo-some no.	rs no.	nt position	SNP location within gene (mRNA transcript no. in NCBI database)	ra in discovery half-sample (n = 492)	r in validation half-sample (n = 492)	p-value using PLINK in the total sample (n = 984)
IL1RL1	2	10208293	102332742	Intron 10 (NM_016232.4)	0.95	0.91	0.002
CTLA4	2	231779	204442732	Intron 1 (NM_005214.3)	−0.99	−0.93	0.028
CD86	3	17203439	123278196	Intron 1 (NM_175862.3)	0.95	0.97	0.016
TLR1	4	5743572	38481786	Intron 2 (NM_003263.3)	0.98	0.93	0.05
DEFB1	8	2978873	6717373	Intron 1 (NM_005218.3)	0.98	0.98	0.016
		2977772	6720606	Intron 1 (NM_005218.3)	0.91	0.94	0.013
MAPK8	10	10857564	49282578	Intron 1 (NM_002750.2)	−0.95	−0.96	0.03
IL17D	13	1888001	20183906	Intron 2 (NM_138284.1)	0.94	0.91	0.018

^ar is the correlation between minor allele frequency and antibody response in EU ml⁻¹.