Figure 2.

Hypothetical composition for secondary and tertiary immunogenic compositions to foster affinity maturation from a diverse starting repertoire. Progressively limited abundance of antigen and epitope focusing to direct evolution towards higher affinity responses to shared epitopes that can access HIV envelopes at approach angles required to reach their targets in neutralization resistant viral variants. The adjuvant formulation would foster Tfh differentiation [24] and plasma cell longevity [25]. Either the priming or boosting immunogen may need to contain common variants of the target epitope incorporated into the immunogen structure.