Table 1.
End Points of Dams Exposed to TCC During GDs 5 to 19.a
| End Point | TCC | ||
|---|---|---|---|
| Control | 0.2% w/w | 0.5% w/w | |
| No. of dams | 4 | 5 | 5 |
| Initial body weight, g | 244.9 ± 10.7 | 253.3 ± 1.6 | 249.5 ± 2.8 |
| GD 19 body weight, g | 339.1 ± 11.1 | 337.8 ± 6.1 | 316.3 ± 5.2 |
| Body weight gain (GDs 5-19), g | 94.2 ± 3.7 | 85.0 ± 6.6 | 66.7 ± 4.7b,c |
| Implantation No. | 14.5 ± 1.0 | 14.8 ± 0.4 | 15.2 ± 0.4 |
| Liver, g | 13.3 ± 0.8 | 13.7 ± 0.6 | 12.1 ± 0.4 |
| Kidney, g | 0.77 ± 0.04 | 0.77 ± 0.03 | 0.73 ± 0.01 |
| Adrenal, mg | 30.8 ± 1.0 | 31.5 ± 1.8 | 33.4 ± 1.5 |
| Ovary, mg | 64.7 ± 2.0 | 63.0 ± 3.1 | 64.3 ± 4.9 |
| Estradiol, pg/mL | 101.8 ± 23.0 | 106.8 ± 2.9 | 100.5 ± 10.7 |
| Progesterone, ng/mL | 102.1 ± 11.0 | 111.4 ± 8.7 | 111.3 ± 14.5 |
| Testosterone, ng/mL | 0.29 ± 0.02 | 0.212 ± 0.02 | 0.218 ± 0.07 |
| T3, ng/mL | 0.63 ± 0.05 | 0.52 ± 0.01 | 0.44 ± 0.03b |
| T4, ng/mL | 22.1 ± 4.1 | 20.9 ± 3.0 | 18.1 ± 2.0 |
| TSH, ng/mL | 13.7 ± 1.9 | 16.0 ± 1.1 | 13.1 ± 1.6 |
Abbreviations: ANOVA, analysis of variance; TCC, triclocarban; GD, gestational day; T3, triiodothyronine; T4, thyroxine; TSH, thyroid-stimulating hormone.
a ANOVA, P < .05.
b Significant from the control group.
c Significant from the 0.2% w/w TCC group.