Table III.

Patient and treatment characteristics of local failures and outcomes following salvage therapy.

Patients	Cohort	Tumor size (cm)	Pattern of failure	Time to failure (months)	Salvage treatment	Outcome
1	No prior WBRT	3.9 X 3.0	Local and distant	8.2	WBRT: 30 Gy/10 with simultaneous boost to GTV of 40 Gy/10	Died 2 months post-salvage from systemic disease, brain locally controlled
2	No prior WBRT	3.4 X 3.6	Local	2.4	WBRT: 20 Gy/5 with simultaneous boost to GTV of 25 Gy/5	Died 6 months post-salvage from CNS disease progression
3	No prior WBRT	2.5 X 2.5	Local	6.0	SRT: 30 Gy/5	Locally controlled 1 month post-SRT
4*	Prior WBRT	3.7 X 3.8	Local and distant	2.2	Surgery alone	Died 3 months post-salvage from CNS disease progression
5*	Prior WBRT	3.5 X 2.9	Local	13.9	Surgery alone	Locally controlled at 4 months
6	Prior WBRT	2.5 X 2.4	Local	6.0	None	Died from CNS disease progression
7*	Prior WBRT	4.3 X 2.9	Local	8.0	Surgery plus WBRT 25 Gy/10	Locally controlled at 5 months

*Patients with resistant disease having had prior surgery followed by WBRT +/− further SRS and subsequently locally relapsed and treated with re-excision and HCSRT, WBRT refers to whole brain radiotherapy, CNS refers to central nervous system, SRT refers to stereotactic radiotherapy.