Table 2.
R18K | L66H | R213W | |
---|---|---|---|
Consurf results | Exposed residue /Highly conserved | Buried residue /Highly conserved | Exposed residue /Highly conserved |
ipTree | Destabilizing | Destabilizing | Destabilizing |
MuStab | Decreased stability | Decreased stability | Increased stability |
Mutation tasting | Disease causing | Disease causing | Disease causing |
pMut | Neutral | Pathological | Pathological |
Polyphen | Damaging | Damaging | Damaging |
SIFT | Tolerated | Not tolerated | Not tolerated |
Conserved | Conserved down to gallus | Conserved down to tropicalis | Conserved down to Fugu |
Domain | zf-C4H2 coiled-coil domain | zf-C4H2 coiled-coil domain | No |