Fig. (7). Acclimatization continuum for perinatal hypoxia-induced lung structure and function responses amongst commonly studied species.

As discussed in the text, there is not only a wide degree of variance between individual species but also there can be variability within species. Llamas and cows are on opposite ends of the spectrum and based on the published studies they have lower variability than rats, dogs, or humans. The responses of newborn sheep are less severe than rodents or cows but the dysfunctions are similar to those found in human infants. The length and placement of the bars provides a subjective ranking based on the amalgamation of information provided in the text. We considered the influence of antenatal hypoxia on: decrease of lung diffusion capacity, elevation in pulmonary artery pressures and subsequent hypertrophy of the right ventricle, muscularization of the small vessels and overall vascular remodeling, increased HPV response, increases or decreases in the reactivity of the vessels to agonists as well as endothelial mediated vessel dilation, evidence of intrauterine growth restriction, and survival.