Skip to main content
. Author manuscript; available in PMC: 2016 Jan 28.
Published in final edited form as: Adv Healthc Mater. 2014 Aug 22;4(2):228–236. doi: 10.1002/adhm.201400337

Figure 5.

Figure 5

GW3965-encapsulated NPs inhibit the progression of atherosclerotic lesions in Ldlr−/− mice. Ldlr-/− mice (n=5) with WD-induced atherosclerotic plaques were treated i.v. for 2 weeks with vehicle, free GW3965 (10 mg/kg), or an equivalent dose of GW3965-encapsulated NPs. (A) Representative CD68+ staining of aortic root lesions (magnification 4x). (B) Quantitative analysis of CD68+ lesion area by ImagePro Plus software. The aortic root sections were analyzed for the expression of LXR target genes ABCA1 and SREBP-1c (C), and inflammatory genes MCP-1 and TNFα (D). Data are represented as the mean ± standard deviation (n=5). *P<0.05 and **P<0.01, as compared with the control group.