Table 4. The number of CpG sites with intra-individual longitudinal changes when using the dual thresholds of absolute difference in the M-value (ΔM) and the False Discovery Rate (FDR)-adjusted P value.

Threshold	Time span	MZ 11A	MZ 11B	C	D	E #	F	G	H
|ΔM| > 1.0 & FDR-adjusted P value < 0.05	3 months (6 m vs. 9 m)	309	357	395	355	99	352	295	306
	6 months (3 m vs. 9 m)	402	413	396	473	129	372	387	N/A*
	9 months (0 m vs. 9 m)	337	876	436	1,514	148	332	307	327
|ΔM| > 1.0 & FDR-adjusted P value < 0.01	3 months (6 m vs. 9 m)	232	257	289	260	58	249	216	224
	6 months (3 m vs. 9 m)	286	285	300	327	85	256	273	N/A
	9 months (0 m vs. 9 m)	230	600	322	1,175	96	229	218	239
|ΔM| > 1.0 & FDR-adjusted P value < 0.001	3 months (6 m vs. 9 m)	153	171	188	188	34	164	145	149
	6 months (3 m vs. 9 m)	187	191	209	207	56	183	177	N/A
	9 months (0 m vs. 9 m)	154	387	208	890	55	147	135	161
|ΔM| > 1.0 & FDR-adjusted P value < 0.0001	3 months (6 m vs. 9 m)	115	123	150	138	25	118	103	115
	6 months (3 m vs. 9 m)	125	148	150	137	37	129	126	N/A
	9 months (0 m vs. 9 m)	112	284	142	698	37	106	96	116

^#: E_{9 m_}1^st used

*: not applicable.