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. 2015 Aug 6;10(8):e0133749. doi: 10.1371/journal.pone.0133749

Fig 2. The nature and distribution of genes containing granulin modules in unicellular organisms, plants, fungi, and metazoa.

Fig 2

Granulin modules are represented as yellow circles. Metazoans possess only progranulins, linear chains of granulin modules that may contain multiple modules or as few as 1.5. Similar progranulin like proteins are found in organisms closely related to metazoans including Choanoflagellates and Filasterea. Granulin-modules are encountered in other unikonts including slime molds and an Apusozoa but appear to be absent from fungi. In Dictyostelium and related slime molds the Grn genes contain one granulin module and a short N-terminal polypeptide tail. Among bikonts, genes containing granulin modules are reliably detected only in green plants (viridiplantae). In plants and some unikonts (Choanoflagellates and Apusozoa), but not in metazoa, the granulin modules are associated with non-granulin proteins (identified in the figure key). The distances between taxa are arbitrary.