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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: JAMA Ophthalmol. 2015 Feb;133(2):182–190. doi: 10.1001/jamaophthalmol.2014.4747

Table.

Summary of Experiments and Integral Intraocular Pressure (IOP)

No. of Rats Time After Treatment, d Light-Cycling Pattern Treatment Dark-Cycle Integral IOP, Mean (SE), mm Hg-days P Value
Model 1
8 31 7 am to 7 pm light Naive 557.8 (9.2) .04
7 pm to 7 am dark scAAV2.dnRhoA 547.8 (9.2)
8 18 7 am to 7 pm light Naive 300.2 (5.5) .52
7 pm to 7 am dark Ad5.dnRhoA 298.9 (5.0)
Model 2
7 54 9 pm to 9 am light scAAV2.GFP 1073.6 (51.7) <.001
9 am to 9 pm 2-lux red light scAAV2.dnRhoA 659.4 (30.4)
7 42 9 pm to 9 am light scAAV2.GFP 698.8 (11.7) .08
9 am to 9 pm 2-lux red light scAAV2.dnRhoA 686.2 (9.1)
Model 3
7 27 11 pm to 11 am light Naive 367.3 (13.3) <.001
11 am to 11 pm dark scAAV2.dnRhoA 265.9 (11.7)