Table 6.
Frequency and Relative Prevalence of Ten Specific Diagnoses Across US Department of Health and Human Services Health Care Regionsa
| Specific Diagnosis | Boston (n = 872) | New York (n = 1,391) | DC (n = 2,312) | Atlanta (n = 5,100) | Chicago (n = 4,444) | Dallas (n = 2,509) | Kansas City (n = 1,120) | Denver (n = 1,281) | San Francisco (n = 3,149) | Seattle (n = 1,201) | p Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AV canal, n (%) | 103 (11.8) | 118 (8.5) | 191 (8.3) | 505 (9.9) | 407 (9.2) | 210 (8.4) | 102 (9.1) | 123 (9.6) | 256 (8.1) | 111 (9.2) | 0.02 |
| 95% CI |
|
7.0–9.9 | 7.1–9.4 | 9.1–10.7 | 8.3–10.0 | 7.3–9.5 | 7.4–10.8 | 8.0–11.2 | 7.2–9.1 | 7.6–10.9 | |
| Truncus arteriosus, n (%) | 13 (1.5) | 24 (1.7) | 36 (1.6) | 99 (1.9) | 74 (1.7) | 52 (2.1) | 19 (1.7) | 28 (2.2) | 64 (2.0) | 17 (1.4) | 0.70 |
| 95% CI | 0.7–2.3 | 1.0–2.4 | 1.1–2.1 |
|
1.3–2.0 | 1.5–2.6 | 0.9–2.5 | 1.4–3.0 | 1.5–2.5 | 0.7–2.1 | |
| Total anomalous pulmonary venous return, n (%) | 28 (3.2) | 44 (3.2) | 64 (2.8) | 172 (3.4) | 146 (3.3) | 100 (4.0) | 40 (3.6) | 44 (3.4) | 138 (4.4) | 50 (4.2) | 0.08 |
| 95% CI | 2.0–4.4 | 2.2–4.1 | 2.1–3.4 | 2.9–3.9 | 2.8–3.8 | 3.2–4.8 | 2.5–4.7 | 2.4–4.4 |
|
3.0–5.3 | |
| Tetralogy of Fallot, n (%) | 93 (10.7) | 171 (12.3) | 285 (12.3) | 582 (11.4) | 454 (10.2) | 237 (9.4) | 120 (10.7) | 105 (8.2) | 327 (10.4) | 112 (9.3) | 0.0006 |
| 95% CI | 8.6–12.7 | 10.6–14.0 |
|
10.5–12.3 | 9.3–11.1 | 8.3–10.6 | 8.9–12.5 | 6.7–9.7 | 9.3–11.5 | 7.7–11.0 | |
| Pulmonary atresia/intact ventricular septum, n (%) | 10 (1.1) | 21 (1.5) | 24 (1.0) | 104 (2.0) | 92 (2.1) | 47 (1.9) | 23 (2.1) | 33 (2.6) | 94 (3.0) | 14 (1.2) | <−.0001 |
| 95% CI | 0.4–1.9 | 0.9–2.2 | 0.6–1.5 | 1.7–2.4 | 1.7–2.5 | 1.3–2.4 | 1.2–2.9 | 1.7–3.4 |
|
0.6–1.8 | |
| Tricuspid atresia, n (%) | 29 (3.3) | 36 (2.6) | 70 (3.0) | 155 (3.0) | 131 (2.9) | 60 (2.4) | 31 (2.8) | 40 (3.1) | 67 (2.1) | 14 (1.2) | 0.009 |
| 95% CI | 2.1–4.5 | 1.8–3.4 | 2.3–3.7 |
|
2.5–3.4 | 1.8–3.0 | 1.8–3.7 | 2.2–4.1 | 1.6–2.6 | 0.6–1.8 | |
| Unbalanced AV canal, n (%) | 2 (0.2) | 12 (0.9) | 25 (1.1) | 68 (1.3) | 78 (1.8) | 15 (0.6) | 5 (0.4) | 2 (0.2) | 35 (1.1) | 6 (0.5) | <−.0001 |
| 95% CI | 0.1–0.5 | 0.4–1.3 | 0.7–1.5 | 1.0–1.6 |
|
0.3–0.9 | 0.1–0.8 | 0.1–0.4 | 0.7–1.5 | 0.1–0.9 | |
| HLHS, n (%) | 92 (10.6) | 150 (10.8) | 235 (10.2) | 560 (11.0) | 451 (10.1) | 293 (11.7) | 133 (11.9) | 120 (9.4) | 287 (9.1) | 111 (9.2) | 0.03 |
| 95% CI | 8.5–12.6 | 9.2–12.4 | 8.9–11.4 | 10.1–11.8 | 9.3–11.0 |
|
10.0–13.8 | 7.8–11.0 | 8.1–10.1 | 7.6–10.9 | |
| Interrupted aortic arch, n (%) | 8 (0.9) | 30 (2.2) | 35 (1.5) | 84 (1.6) | 80 (1.8) | 36 (1.4) | 18 (1.6) | 18 (1.4) | 70 (2.2) | 25 (2.1) | 0.14 |
| 95% CI | 0.3–1.6 | 1.4–2.9 | 1.0–2.0 | 1.3–2.0 | 1.4–2.2 | 1.0–1.9 | 0.9–2.3 | 0.8–2.1 |
|
1.3–2.9 | |
| TGA, n (%) | 82 (9.4) | 101 (7.3) | 179 (7.7) | 317 (6.2) | 324 (7.3) | 138 (5.5) | 111 (9.9) | 80 (6.2) | 230 (7.3) | 95 (7.9) | <−.0001 |
| 95% CI | 7.5–11.3 | 5.9–8.6 | 6.7–8.8 | 5.6–6.9 | 6.5–8.1 | 4.6–6.4 |
|
4.9–7.6 | 6.4–8.2 | 6.4–9.4 |
a
For each diagnostic group, the region with the highest 5% CI is boxed and those regions for which there is no overlap with this CI are italicized.
AV = atrioventricular; CI = confidence interval; HLHS = hypoplastic left heart syndrome; TGA = transposition of the great arteries.