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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Calcif Tissue Int. 2015 Jun 6;97(3):281–291. doi: 10.1007/s00223-015-0016-3

Figure 3.

Figure 3

Electron Microscopy images of 2-month-old wild type (A–C) and Bgn-Dcn−/−;−/− (D–F) mouse tibiae. (B) and (F) are TEM images of (A) and (D) modified for improved visualization of collagen fibril profiles. In Bgn-Dcn−/−;−/− mice the collagen fibrils appear serrated and lack circular cross-sectional profile. The typical collagenous texture seen in WT (C) from quantitative backscattered electron imaging was completely loss in the mutant (F) and replaced by a uniform glassy mineralized matrix. From Corsi et al [43] with permission obtained from Journal of Bone and Mineral Research.