Table 1.

Summary of morphological changes and structural properties of NCP mouse models.

Mouse Model	Morphological Traits (compared to WT)	Type of Mechanical Test	Structural Mechanical Properties (compared to WT)	Ref
Osteocalcin (OC−/−)	Increased bone mass and cortical thickness	Strength	Increased ultimate load	[8]
Biglycan (Bgn−/−)	Reduced bone length, bone mass and cortical thickness	Strength	Reduced bone strength and ductility	[31]
Fibrillin-2 (Fbn2−/−)	Decreased length and BMD, thick cortex	Strength	Decreased in stiffness, maximum load and total work	[32]
Osteonectin (SPARC)	Decreased cortical and trabecular bone mass	Strength	Decreased stiffness and maximum load	[34]
Periostin (Postn−/−)	Decreased cortical and trabecular bone mass	Strength	Reduced stiffness, ultimate force and strength	[35,36]
Bone Sialoprotein (BSP−/−)	Reduced length, BMD and thinner cortices	NA	NA	[38]
Matrix Extracellular Protein (OF45−/−)	Increase endosteal and periosteal circumference, increased trabecular bone content	NA	NA	[37]
Osteopontin (OPN−/−)	NA	Strength	Increased elastic modulus, decreased maximum load, work to fracture and post yield deformation	[40]