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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Cancer Discov. 2015 Jun 11;5(8):860–877. doi: 10.1158/2159-8290.CD-14-1236

Figure 1. Consensus NMF clustering identifies three robust and reproducible subsets of KRAS-mutant LUAC.

Figure 1

(A) Consensus matrices of 68 KRAS-mutant LUACs from the TCGA dataset, computed for k=2 to k=7.

(B) Cophenetic correlation coefficient plot reveals peak cluster stability for k=3 ranks.

(C) Heatmap depicting mRNA expression levels of 384 genes selected for the NMF algorithm.

(D) Relative expression levels of individual genes that comprise the 18-gene cluster assignment signature in LUACs from the TCGA dataset.

(E) Cluster composition is preserved across distinct datasets of chemotherapy-naïve (PROSPECT, CHITALE) and platinum-refractory (BATTLE-2) KRAS-mutant LUACs.

(F) Subgroup representation is unaffected by increasing disease stage. Stage 4 platinum refractory tumors in this analysis represent the BATTLE-2 clinical cohort.