Figure 7.

Comparison of [¹¹C]OMAR blood and brain data between genders. (A) Plasma protein binding did not differ between sexes (P=0.78). (B) Fraction of radioactivity in the plasma attributable to the parent compound was greater in men than women (P<0.0001 for global effect of gender). (C) Whole blood and (D) total plasma radioactivity concentrations were greater in men (P<0.0001 for global effect as well as for interaction between sex and time). (E) Net brain uptake of [¹¹C]OMAR, as reflected by SUV over the 0 to 120-minute window, was ~17% greater in men across brain regions (P<0.0001 for effect of sex). (F) Regional V_T values estimated by multilinear analysis (MA1) were ~23% greater in women than men (P<0.0001). Data from men are depicted by open markers/bars and data from women by filled markers/bars. *P<0.05 and ^#0.05⩽P<0.1, adjusted P values after Bonferroni correction for multiple comparisons.