Figure 5.

Multitrauma induces behavioral abnormalities in the open-field and motor dysfunction on the rotarod. The MULTI group spent more time (A) and made more entries (B) in the center area of the open-field in comparison with SHAM, FX, and TBI groups. There were no differences in the distance traveled (C). There were no significant differences on the measure of duration on rotarod during training (D). However, during testing the MULTI group spent significantly less time on the rotarod (E) than both the SHAM and TBI groups. ***Greater than all other groups, P<0.05. **Less than SHAM and TBI groups; P<0.05. FX, tibial fracture; MULTI, multitrauma; SHAM, sham-injuries; TBI, traumatic brain injury.