Table 3.
Univariate and multivariate analyses in colorectal cancer tissue specimens (n = 712)
| Variables |
Overall survival |
Disease-free survival |
||
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Univariate analyses | ||||
| Sex (male vs female) | 0.84 (0.58-1.23) | 0.376 | 0.86 (0.63-1.18) | 0.342 |
| Age (≥ 60 yr vs < 60 yr) | 1.24 (0.85-1.80) | 0.259 | 0.95 (0.69-1.30) | 0.734 |
| TNM stage (IV/III vs II/I) | 3.11 (2.06-4.70) | < 0.001 | 2.37 (1.72-3.27) | < 0.001 |
| Differentiation (poor/mucinous adenocarcinoma vs well/moderate) | 1.54 (0.93-2.55) | 0.094 | 1.33 (0.85-2.08) | 0.219 |
| Position (rectal vs colon) | 0.56 (0.38-0.83) | 0.003 | 0.92 (0.66-1.23) | 0.506 |
| CEA (≥ 5 ng/mL vs < 5 ng/mL) | 1.97 (1.36-2.85) | < 0.001 | 1.63 (1.19-2.21) | 0.002 |
| CA19-9 (≥ 37 U/mL vs < 37 U/mL) | 2.27 (1.50-3.42) | < 0.001 | 1.89 (1.31-2.72) | 0.001 |
| NLK (++/+++ vs -/+) | 2.19 (1.44-3.35) | < 0.001 | 2.71 (1.86-3.94) | < 0.001 |
| Postoperative radiochemotherapy (yes vs no) | 2.42 (1.30-4.51) | 0.005 | 2.69 (1.60-4.50) | < 0.001 |
| Multivariate analyses | ||||
| TNM stage (IV/III vs II/I) | 3.02 (1.99-4.59) | < 0.001 | 2.34 (1.70-3.22) | < 0.001 |
| Differentiation (poor/mucinous adenocarcinoma vs well/moderate) | 1.78 (1.06-2.98) | 0.029 | 1.45 (0.94-2.24) | 0.091 |
| Position (rectal vs colon) | 0.49 (0.33-0.72) | < 0.001 | 0.80 (0.59-1.08) | 0.143 |
| CEA (≥ 5 ng/mL vs < 5 ng/mL) | 1.56 (1.04-2.35) | 0.032 | 1.31 (0.95-1.81) | 0.099 |
| CA19-9 (≥ 37 U/mL vs < 37 U/mL) | 1.54 (0.99-2.41) | 0.058 | 1.76 (1.24-2.49) | 0.002 |
| NLK (++/+++ vs -/+) | 2.57 (1.66-3.98) | < 0.001 | 1.96 (1.40-2.74) | < 0.001 |
| Postoperative radiochemotherapy (yes vs no) | 1.04 (0.50-2.16) | 0.921 | 1.64 (0.93-2.92) | 0.090 |
CA19-9: Cancer antigen 19-9; CEA: Carcinoembryonic antigen; CI: Confidence interval; HR: Hazard ratio; NLK: Nemo-like kinase; TNM: Tumor-node-metastasis.